Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition
نویسندگان
چکیده
منابع مشابه
Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition.
Airway dehydration causes mucus stasis and bacterial overgrowth in cystic fibrosis and chronic bronchitis (CB). Rehydration by hypertonic saline is efficacious but suffers from a short duration of action. We tested whether epithelial sodium channel (ENaC) inhibition would rehydrate normal and dehydrated airways to increase mucociliary clearance (MCC) over a significant time frame. For this, we ...
متن کاملPulmonary radioaerosol mucociliary clearance in primary ciliary dyskinesia.
Primary ciliary dyskinesia (PCD) is a genetic condition affecting one in 10 000–40 000 people from birth [1]; cilia fail to beat, and the airway clearance of mucus and debris is severely impaired. If untreated, this results in progressive lung infection leading to bronchiectasis and ultimately respiratory failure. Additionally, delayed diagnosis has implications for genetic counselling, appropr...
متن کاملMucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists
OBJECTIVES There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution. METHODS In total, 25 non-smoking commercial motorcyclists, aged 18-44 years, ...
متن کامل[Airway calcium deposition and broncholithiasis in disorders of mucociliary clearance].
To the Editor: We read with interest the report by García Pachón et al1 regarding idiopathic chronic lithoptysis and the letter by Roig Vázquez et al2 on lithoptysis in a patient with primary ciliary dyskinesia (PCD). Complementing these observations, we recently completed an analysis of lithoptysis and airway calcification in a large cohort (n=142) of wellcharacterized PCD patients.3 We identi...
متن کاملIL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells.
In animal models of asthma, interleukin-13 (IL-13) induces goblet cell metaplasia, eosinophil infiltration of the bronchial mucosa, and bronchial hyperreactivity, but the basis of its effects on airway epithelia remain unknown. Lesions of the epithelial barrier, frequently observed in asthma and other chronic lung inflammatory diseases, are repaired through proliferation, migration, and differe...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2015
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00163.2014